We Make Bioorganic
Chemistry Happen
We Make Bioorganic
Chemistry Happen
Rooted in glycochemistry, we deliver custom synthesis of complex molecules across glycans, peptides, RNA, and conjugates.
Rooted in glycochemistry, we deliver custom synthesis of complex molecules across glycans, peptides, RNA, and conjugates.
Areas of Expertise
With glycochemistry at our core, we make difficult chemistry work.
Glycans & Carbohydrate Derivatives
Glycosylations & protecting group strategies
Modified sugars (L-, deoxy-, azido-)
Oligosaccharides & glycoconjugates
RNA & Nucleotide Building Blocks
RNA building blocks & modified nucleotides
siRNA & oligonucleotide constructs
Enzyme substrates & derivatives
Peptides & Amino Acid Derivatives
Unnatural amino acids
Peptides
Functionalized Derivatives
Conjugates & Linker Systems
Protein & antibody conjugation linkers
Glyco-, peptido- and hybrid systems
Amphiphilic molecules
Glycans & Carbohydrate Derivatives
Glycosylations & protecting group strategies
Modified sugars (L-, deoxy-, azido-)
Oligosaccharides & glycoconjugates
Peptides & Amino Acid Derivatives
Unnatural amino acids
Peptides
Functionalized Derivatives
RNA & Nucleotide Building Blocks
RNA building blocks & modified nucleotides
siRNA & oligonucleotide constructs
Enzyme substrates & derivatives
Conjugates & Linker Systems
Protein & antibody conjugation linkers
Glyco-, peptido- and hybrid systems
Amphiphilic molecules
How We Support Your Project
Focused on challenging synthesis, from route design to reliable material.
Route Design
Designing viable synthesis routes for difficult target molecules.
Development of strategies for complex molecules
Resolution of bottlenecks and dead ends in existing routes
Early assessment of feasibility and scalability
Fast iteration toward a reliable working route
Process Optimization
Making difficult reactions work reliably at laboratory scale.
Improvement of yield, selectivity, and reproducibility
Identification and control of side reactions and impurities
Development of robust reaction and purification conditions
Preparation of processes suitable for production
Material Supply
Supply of small-scale quantities based on developed processes.
Manufacturing from milligram to multi-kilogram scale
Reference materials for analytical characterization
Non-GMP and small-scale GMP in-house capabilities
Tech transfer support for large-scale manufacturing
Route Design
Designing viable synthesis routes for difficult target molecules.
Development of strategies for complex molecules
Resolution of bottlenecks and dead ends in existing routes
Early assessment of feasibility and scalability
Fast iteration toward a reliable working route
Process Optimization
Making difficult reactions work reliably at laboratory scale.
Improvement of yield, selectivity, and reproducibility
Identification and control of side reactions and impurities
Development of robust reaction and purification conditions
Preparation of processes suitable for production
Material Supply
Supply of small-scale quantities based on developed processes.
Manufacturing from milligram to multi-kilogram scale
Reference materials for analytical characterization
Non-GMP and small-scale GMP in-house capabilities
Tech transfer support for large-scale manufacturing
Technical Capabilities
In-house development across the scale, from discovery to production.
Synthesis & Scale Range
250 mL to 160 L reaction scale
Low-temperature chemistry down to –60 °C
Parallel setups for rapid route iteration
Hydrogenation and specialized reactions in-house
Conditions designed for reproducible and robust scale-up
OligoPilot 100 for solid phase-synthesis
Analytical & Process Insight
GMP-qualified NMR (1H, 13C, 19F, 31P)
LC-MS for reaction monitoring and profiling
HPLC-UV/MS and CAD purity analysis
Identification of side products
Karl-Fischer
GMP-qualified NMR (1H, 13C, 19F, 31P)
LC-MS for reaction monitoring and profiling
HPLC-UV/MS and CAD purity analysis
Identification of side products
Karl-Fischer
Purification & Isolation
Chromatography up to 20 kg silica
Prep HPLC, MPLC, and flash systems
Lyophilization for sensitive compound isolation
Expertise in polar and complex molecules
Purification aligned with scale-up requirements
Crystallization screening (Crystal16)
Scale-Up & Tech Transfer
Internal scale-up and scalability approval
Development of robust procedures
Processes designed for scalability from start
Potential tech transfer to external manufacturing
Multi-100 kg production via external network
Synthesis & Scale Range
250 mL to 160 L reaction scale
Low-temperature chemistry down to –60 °C
Parallel setups for rapid route iteration
Hydrogenation and specialized reactions in-house
Conditions designed for reproducible and robust scale-up
OligoPilot 100 for solid phase-synthesis
Purification & Isolation
Chromatography up to 20 kg silica
Prep HPLC, MPLC, and flash systems
Lyophilization for sensitive compound isolation
Expertise in polar and complex molecules
Purification aligned with scale-up requirements
Crystallization screening (Crystal16)
Analytical & Process Insight
GMP-qualified NMR (1H, 13C, 19F, 31P)
LC-MS for reaction monitoring and profiling
HPLC-UV/MS and CAD purity analysis
Identification of side products
Karl-Fischer
Scale-Up & Tech Transfer
Internal scale-up and scalability approval
Development of robust procedures
Processes designed for scalability from start
Potential tech transfer to external manufacturing
Multi-100 kg production via external network
Quality and Regulatory Compliance
GMP Manufacturing for Early Clinical Supply
We provide GMP-grade material at multi-gram scale for active pharmaceutical ingredients, supporting early clinical phases (I/II) in full compliance with ICH Q7 (Chapter 19).
Dedicated GMP Laboratory Infrastructure
Our GMP laboratory enables controlled synthesis, purification, and final product isolation — including advanced chromatography, lyophilization, and compliant sampling procedures.
Regulatory Oversight and Inspection
Regular inspections by Swissmedic and ongoing client audits ensure consistent adherence to regulatory requirements and reinforce confidence in data integrity and product quality.
Certified Quality Management System
Our operations are aligned with ISO 9001, ensuring structured, traceable, and continuously monitored processes across all projects.
About us
Dr. Arthur Bodenmüller
CEO & Founder
"Founded in 2000, SynphaBase has grown from an academic spin-off into a trusted Swiss CDRO specializing in complex carbohydrate synthesis. With deep roots in glycoscience and over 2,000 successful projects, we support pharmaceutical innovators from route scouting to late-stage clinical supply.
Our strength lies in combining high-purity synthesis with expert process development — always guided by precision, flexibility, and quality. ISO 9001 certified and Swissmedic compliant, we deliver value-based solutions that scale, adapt, and accelerate your path to market."
Dr. Arthur Bodenmüller
CEO & Founder
"Founded in 2000, SynphaBase has grown from an academic spin-off into a trusted Swiss CDRO specializing in complex carbohydrate synthesis. With deep roots in glycoscience and over 2,000 successful projects, we support pharmaceutical innovators from route scouting to late-stage clinical supply.
Our strength lies in combining high-purity synthesis with expert process development — always guided by precision, flexibility, and quality. ISO 9001 certified and Swissmedic compliant, we deliver value-based solutions that scale, adapt, and accelerate your path to market."
Dr. Arthur Bodenmüller
CEO & Founder
"Founded in 2000, SynphaBase has grown from an academic spin-off into a trusted Swiss CDRO specializing in complex carbohydrate synthesis. With deep roots in glycoscience and over 2,000 successful projects, we support pharmaceutical innovators from route scouting to late-stage clinical supply.
Our strength lies in combining high-purity synthesis with expert process development — always guided by precision, flexibility, and quality. ISO 9001 certified and Swissmedic compliant, we deliver value-based solutions that scale, adapt, and accelerate your path to market."
What our customers say
Shiri Zemer-Goft
Senior Director
89bio (Member of Roche Group)
"Synphabase has talented scientists with deep expertise in the field of carbohydrate chemistry. We were able to utilize their experience, in combination with the capability to design new routes, and make first Kg amounts in a relatively short time enabling advanced drug development activities."
Dr. M Stohlmeier
Senior Product Manager
Chemie Uetikon AG (now Seqens)
"The process description we received, based on the excellent laboratory development of SynphaBase and the approval on a pilot scale, could be scaled up quickly and easily in our devices. Since then, we have been producing the substance on a multi-ton scale with very high reproducibility in terms of yield and quality."
Martin Knüsel
Managing Director
Merck & Cie KmG
"We firmly believe that our collaboration with SynphaBase AG will continue to drive significant advancements in carbohydrate synthesis, ultimately contributing to our shared goal of improving global health outcomes. Thank you, Synphabase AG, for your invaluable partnership."
Shiri Zemer-Goft
Senior Director
89bio (Member of Roche Group)
"Synphabase has talented scientists with deep expertise in the field of carbohydrate chemistry. We were able to utilize their experience, in combination with the capability to design new routes, and make first Kg amounts in a relatively short time enabling advanced drug development activities."
Dr. M Stohlmeier
Senior Product Manager
Chemie Uetikon AG (now Seqens)
"The process description we received, based on the excellent laboratory development of SynphaBase and the approval on a pilot scale, could be scaled up quickly and easily in our devices. Since then, we have been producing the substance on a multi-ton scale with very high reproducibility in terms of yield and quality."
Martin Knüsel
Managing Director
Merck & Cie KmG
"We firmly believe that our collaboration with SynphaBase AG will continue to drive significant advancements in carbohydrate synthesis, ultimately contributing to our shared goal of improving global health outcomes. Thank you, Synphabase AG, for your invaluable partnership."
Our Values
DRIVEN BY RESULTS
We measure our success by the value we create for our clients. Every project is approached with focus, efficiency, and a commitment to delivering high-impact outcomes — from lab-scale to clinical supply.
POWERED BY PEOPLE
Our strength lies in our people. We harness individual expertise, foster collaboration, and create an environment where trust, ownership, and continuous growth drive innovation.
UNITED BY PURPOSE
We are bound by a shared mission: to enable meaningful medicines through glycoscience. This common purpose shapes our decisions, fuels our dedication, and connects our work to a greater good.
DRIVEN BY RESULTS
We measure our success by the value we create for our clients. Every project is approached with focus, efficiency, and a commitment to delivering high-impact outcomes — from lab-scale to clinical supply.
POWERED BY PEOPLE
Our strength lies in our people. We harness individual expertise, foster collaboration, and create an environment where trust, ownership, and continuous growth drive innovation.
UNITED BY PURPOSE
We are bound by a shared mission: to enable meaningful medicines through glycoscience. This common purpose shapes our decisions, fuels our dedication, and connects our work to a greater good.
Contact us
We are happy to hear from you. Reach us directly via phone or email.
Olaf Bartram
Manager Marketing & Business Development
Our Location
Güterstrasse 98 • 4133 Pratteln • Switzerland